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1.
Benzopyrone, a privileged scaffold in drug discovery: An overview of FDA-approved drugs and clinical candidates.
Med Res Rev
; 2024 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38532246
2.
Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors.
PLoS Pathog
; 17(7): e1009706, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34252168
3.
Discovery of blood-brain barrier permeable and orally bioavailable caffeine-based amide derivatives as acetylcholinesterase inhibitors.
Bioorg Chem
; 139: 106719, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37473478
4.
Multitargeted C9-substituted ester and ether derivatives of berberrubine for Alzheimer's disease: Design, synthesis, biological evaluation, metabolic stability, and pharmacokinetics.
Drug Dev Res
; 84(1): 121-140, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36461610
5.
Analyzing the scaffold diversity of cyclin-dependent kinase inhibitors and revisiting the clinical and preclinical pipeline.
Med Res Rev
; 42(2): 654-709, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34605036
6.
Plant growth promoting potential of butyl isobutyl phthalate and Streptomyces sp. from Rumex dentatus on rice.
Appl Microbiol Biotechnol
; 106(7): 2603-2617, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35262787
7.
Antimicrobial and Cytotoxic Potential of Helminthosporin from Rumex abyssiniscus Jacq. Discovered as a Novel Source of Syringic Acid and Bis(2-ethyloctyl) Phthalate.
Curr Microbiol
; 80(1): 7, 2022 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36445554
8.
Blood-brain barrier permeable benzylpiperidin-4-yl-linked benzylamino benzamides as dual cholinesterase inhibitors.
Drug Dev Res
; 83(8): 1791-1802, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36112736
9.
Design, synthesis, and structure-activity relationship of caffeine-based triazoles as dual AChE and BACE-1 inhibitors.
Drug Dev Res
; 83(8): 1803-1821, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36161804
10.
Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization.
Toxicol Appl Pharmacol
; 423: 115582, 2021 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34019860
11.
Identification of aplysinopsin as a blood-brain barrier permeable scaffold for anti-cholinesterase and anti-BACE-1 activity.
Bioorg Chem
; 107: 104568, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33418314
12.
Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-ß structure based virtual screening.
Bioorg Chem
; 95: 103500, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31869665
13.
Discovery of Quinazolin-4(3 H)-ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-Free Synthesis, and in Vitro Biological Evaluation.
J Org Chem
; 84(9): 5129-5140, 2019 05 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30896160
14.
Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast.
Bioorg Med Chem Lett
; 29(3): 454-460, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30579794
15.
Synthesis and biological evaluation of indoloquinoline alkaloid cryptolepine and its bromo-derivative as dual cholinesterase inhibitors.
Bioorg Chem
; 90: 103062, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31220673
16.
Radicicol rescues yeast cell death triggered by expression of human α-synuclein and its A53T mutant, but not by human ßA4 peptide and proapoptotic protein bax.
Bioorg Chem
; 85: 152-158, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30612081
17.
Identification of embelin, a 3-undecyl-1,4-benzoquinone from Embelia ribes as a multitargeted anti-Alzheimer agent.
Drug Dev Res
; 80(5): 655-665, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31050027
18.
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Bioorg Med Chem
; 26(23-24): 6076-6086, 2018 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30448188
19.
Oxidant-Controlled C-sp2/sp3-H Cross-Dehydrogenative Coupling of N-Heterocycles with Benzylamines.
J Org Chem
; 82(18): 9786-9793, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28820259
20.
Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.
Bioorg Med Chem Lett
; 27(24): 5400-5403, 2017 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29150398