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1.
Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration.
Proc Natl Acad Sci U S A
; 118(6)2021 02 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33526699
2.
Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.
Nat Chem Biol
; 16(1): 31-41, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31792442
3.
Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A "structure-activity relationship" perspective.
Med Res Rev
; 38(4): 1404-1442, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29278273
4.
HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1.
Biochem Biophys Res Commun
; 458(1): 14-20, 2015 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25603055
5.
Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists.
Bioorg Med Chem Lett
; 25(7): 1546-51, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25765911
6.
Synthesis and in vitro evaluation of the antitubercular and antibacterial activity of novel oxazolidinones bearing octahydrocyclopenta[c]pyrrol-2-yl moieties.
Chem Pharm Bull (Tokyo)
; 62(12): 1214-24, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25297523
7.
Brain-Permeable Immunoproteasome-Targeting Macrocyclic Peptide Epoxyketones for Alzheimer's Disease.
J Med Chem
; 67(9): 7146-7157, 2024 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38636481
8.
Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease.
J Med Chem
; 64(15): 10934-10950, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34309393
9.
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.
Sci Adv
; 7(40): eabj3658, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34586848
10.
Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy.
J Med Chem
; 63(10): 5139-5158, 2020 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32315177
11.
LMP2 Inhibitors as a Potential Treatment for Alzheimer's Disease.
J Med Chem
; 63(7): 3763-3783, 2020 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32189500
12.
H727 cells are inherently resistant to the proteasome inhibitor carfilzomib, yet require proteasome activity for cell survival and growth.
Sci Rep
; 9(1): 4089, 2019 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30858500
13.
Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy To Overcome Cancer Resistance to Carfilzomib and Bortezomib.
J Med Chem
; 62(9): 4444-4455, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30964987
14.
A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer's disease.
Sci Rep
; 9(1): 18393, 2019 12 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31804556
15.
Correction to "Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease".
J Med Chem
; 67(6): 5109-5110, 2024 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38471117
16.
Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors.
Eur J Med Chem
; 125: 1036-1050, 2017 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27810591
17.
An Insight into Drug Repositioning for the Development of Novel Anti-Cancer Drugs.
Curr Top Med Chem
; 16(19): 2156-68, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26881715
18.
Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells.
BMB Rep
; 48(12): 691-5, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26077028
19.
Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors.
J Med Chem
; 57(22): 9522-38, 2014 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25356789
20.
2-(trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate suppresses osteoclast maturation and bone resorption by targeting macrophage-colony stimulating factor signaling.
Mol Cells
; 37(8): 628-35, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25139265