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1.
Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors.
Eur J Med Chem
; 254: 115331, 2023 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37094451
2.
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ß2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
J Med Chem
; 65(15): 10233-10250, 2022 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35901125
3.
Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives.
RSC Adv
; 11(41): 25504-25509, 2021 Jul 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35478867
4.
Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists.
Bioorg Med Chem Lett
; 20(16): 4741-4, 2010 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20630754
5.
Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists.
Bioorg Med Chem Lett
; 20(23): 7120-3, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20951033
6.
Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists.
Bioorg Med Chem Lett
; 20(20): 6103-7, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20813523
7.
The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists.
Bioorg Med Chem Lett
; 20(24): 7341-4, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21074426
8.
The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.
Bioorg Med Chem Lett
; 19(15): 4022-5, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19581086
9.
Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs.
J Med Chem
; 60(10): 4304-4315, 2017 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28489362
10.
Non-regioselective functionalization: an underestimate chemical diversity generator in medicinal chemistry.
Future Med Chem
; 13(7): 595-599, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33657835
11.
Gene expression and biochemical changes of carbohydrate metabolism in in vitro micro-propagated apple plantlets infected by 'Candidatus Phytoplasma mali'.
Plant Physiol Biochem
; 70: 311-7, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23811119
12.
Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist.
J Med Chem
; 53(23): 8228-40, 2010 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-21053897
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