Detalles de la búsqueda
1.
Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo.
Circ Res
; 117(4): 376-87, 2015 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-26129975
2.
Second generation S1P pathway modulators: research strategies and clinical developments.
Biochim Biophys Acta
; 1841(5): 745-58, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24239768
3.
Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation.
Toxicol Pathol
; 43(5): 694-703, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25630683
4.
Assay to measure the secretion of sphingosine-1-phosphate from cells induced by S1P lyase inhibitors.
Biochem Biophys Res Commun
; 433(3): 345-8, 2013 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-23499842
5.
Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors.
Anal Biochem
; 434(2): 247-53, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23246729
6.
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Nat Chem Biol
; 5(6): 428-34, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19430484
7.
Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice.
Lipids Health Dis
; 9: 1, 2010 Jan 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-20053284
8.
Efficient elimination of nonstoichiometric enzyme inhibitors from HTS hit lists.
J Biomol Screen
; 14(6): 679-89, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19470716
9.
Sphingolipid metabolizing enzymes as novel therapeutic targets.
Subcell Biochem
; 49: 487-522, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18751924
10.
Synthesis of 7-aza- and 7-thiasphingosines, and evaluation of their interaction with sphingosine kinases and with T-cells.
Chem Biodivers
; 6(5): 725-38, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19479838
11.
Synthesis and evaluation of sphingolipid analogues: modification of the hydroxy group at C(1) of 7-oxasphingosine, and of the hydroxy group at C(1) and the amide group of 7-oxaceramides.
Chem Biodivers
; 6(5): 705-24, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19479849
12.
4,5,6-Trisubstituted piperidinones as conformationally restricted ceramide analogues: synthesis and evaluation as inhibitors of sphingosine and ceramide kinases and as NKT cell-stimulatory antigens.
Chem Biodivers
; 6(10): 1688-715, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19842132
13.
Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.
J Med Chem
; 62(23): 10816-10832, 2019 12 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31729873
14.
Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor.
Mol Pharmacol
; 74(4): 925-32, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18612076
15.
Binding of pimecrolimus and tacrolimus to skin and plasma proteins: implications for systemic exposure after topical application.
Drug Metab Dispos
; 36(9): 1812-8, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18524871
16.
Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.
Cell Signal
; 19(4): 748-60, 2007 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-17113265
17.
Interferon regulatory factor 5 and nuclear factor kappa-B exhibit cooperating but also divergent roles in the regulation of pro-inflammatory cytokines important for the development of TH1 and TH17 responses.
FEBS J
; 285(16): 3097-3113, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29971953
18.
Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
J Med Chem
; 61(15): 6724-6735, 2018 08 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29990434
19.
FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.
FEBS Lett
; 581(16): 3063-8, 2007 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-17555747
20.
Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice.
Immunol Lett
; 109(1): 56-63, 2007 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17292973