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1.
SAH derived potent and selective EZH2 inhibitors.
Bioorg Med Chem Lett
; 25(7): 1532-7, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25746813
2.
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
Cell Chem Biol
; 30(10): 1191-1210.e20, 2023 10 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37557181
3.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
ACS Med Chem Lett
; 11(6): 1175-1184, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32550998
4.
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J Med Chem
; 61(3): 650-665, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29211475
5.
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
J Med Chem
; 60(23): 9617-9629, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29111717
6.
Analysing the output from primary screening.
Comb Chem High Throughput Screen
; 9(5): 331-7, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16787146
7.
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun
; 7: 11384, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27122193
8.
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(18): 8306-25, 2016 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27512831
9.
Comparison of a High-Throughput Mass Spectrometry Method and Radioactive Filter Binding to Assay the Protein Methyltransferase PRMT5.
Assay Drug Dev Technol
; 13(4): 235-40, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26065559
10.
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(24): 11196, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27936698
11.
A fluorescence polarization assay for screening inhibitors against the ribonuclease H activity of HIV-1 reverse transcriptase.
Anal Biochem
; 351(2): 260-5, 2006 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16527235
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