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1.
Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
BMC Biol
; 20(1): 182, 2022 08 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35986286
2.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30962368
3.
Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.
Bioorg Med Chem Lett
; 29(12): 1454-1458, 2019 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31005442
4.
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Bioorg Med Chem Lett
; 29(20): 126675, 2019 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31521475
5.
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat Chem Biol
; 11(3): 189-91, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25622091
6.
Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675].
Bioorg Med Chem Lett
; 30(2): 126771, 2020 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31859161
7.
Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
J Med Chem
; 67(3): 2049-2065, 2024 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38284310
8.
Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System.
SLAS Discov
; 26(5): 663-675, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33783261
9.
Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation.
Antibodies (Basel)
; 10(4)2021 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34698051
10.
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
J Invest Dermatol
; 141(9): 2272-2279, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33744298
11.
Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes.
J Med Chem
; 62(17): 8274-8283, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31393717
12.
Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.
Neurosci Lett
; 673: 44-50, 2018 04 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29499308
13.
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.
J Med Chem
; 59(6): 2452-67, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26938474
14.
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors.
ACS Med Chem Lett
; 7(4): 379-84, 2016 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27096045
15.
Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.
ACS Med Chem Lett
; 6(8): 919-24, 2015 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26288694
16.
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.
J Med Chem
; 58(18): 7140-63, 2015 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26090771
17.
Single-molecule detection technologies in miniaturized high-throughput screening: fluorescence intensity distribution analysis.
J Biomol Screen
; 8(1): 19-33, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12854995
18.
A modular, fully integrated ultra-high-throughput screening system based on confocal fluorescence analysis techniques.
J Biomol Screen
; 8(6): 648-59, 2003 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-14711390
19.
Identification of essential residues within Lit, a cell death peptidase of Escherichia coli K-12.
Biochemistry
; 43(24): 7948-53, 2004 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-15196039
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