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1.
Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg Med Chem Lett
; 90: 129331, 2023 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37187252
2.
Incorporating Target-Specific Pharmacophoric Information into Deep Generative Models for Fragment Elaboration.
J Chem Inf Model
; 62(10): 2280-2292, 2022 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35499971
3.
Characterizing the binding and function of TARP γ8-selective AMPA receptor modulators.
J Biol Chem
; 295(43): 14565-14577, 2020 10 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32747446
4.
Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1.
Bioorg Med Chem Lett
; 29(4): 668-673, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30554956
5.
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
Bioorg Med Chem Lett
; 29(19): 126610, 2019 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31471167
6.
Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
Bioorg Med Chem Lett
; 29(3): 509-514, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30553738
7.
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Bioorg Med Chem Lett
; 28(19): 3168-3173, 2018 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30174152
8.
Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1.
Antimicrob Agents Chemother
; 58(10): 6032-43, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25070106
9.
Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
Front Mol Neurosci
; 17: 1370509, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38685916
10.
Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Bioorg Med Chem Lett
; 23(10): 3064-9, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23570789
11.
Identification of novel p-cresol inhibitors that reduce Clostridioides difficile's ability to compete with species of the gut microbiome.
Sci Rep
; 13(1): 9492, 2023 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37303029
12.
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
Bioorg Med Chem Lett
; 22(23): 7169-73, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23099093
13.
Fragment-based target screening as an empirical approach to prioritising targets: a case study on antibacterials.
Drug Discov Today
; 2020 Sep 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32920060
14.
Design of the LifeArc Index Set and Retrospective Review of Its Performance: A Collection for Sharing.
SLAS Discov
; 24(3): 332-345, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30290126
15.
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.
J Med Chem
; 61(10): 4335-4347, 2018 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29701962
16.
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem Biol
; 12(11): 2906-2914, 2017 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-29045126
17.
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover.
Sci Rep
; 7(1): 16693, 2017 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29196708
18.
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Nat Commun
; 8(1): 430, 2017 09 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28874661
19.
Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger.
ACS Chem Biol
; 9(12): 2864-74, 2014 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-25323450
20.
Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
J Med Chem
; 57(8): 3570-87, 2014 Apr 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24689770