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1.
Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.
Mol Cell Proteomics
; 10(11): M111.009183, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21873567
2.
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Nat Cell Biol
; 4(11): 901-6, 2002 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12402047
3.
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem J
; 430(3): 461-76, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20632995
4.
Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Bioorg Med Chem Lett
; 20(22): 6581-6, 2010 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20875739
5.
The JAMM motif of human deubiquitinase Poh1 is essential for cell viability.
Mol Cancer Ther
; 6(1): 262-8, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17237285
6.
p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest.
Mol Biol Cell
; 14(5): 2071-87, 2003 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12802076
7.
Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib.
Mol Cancer Ther
; 5(12): 3052-61, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17172407
8.
Pharmacodynamic monitoring of (immuno)proteasome inhibition during bortezomib treatment of a critically ill patient with lupus nephritis and myocarditis.
Lupus Sci Med
; 2(1): e000121, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26719810
9.
Evidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells.
Br J Pharmacol
; 138(7): 1340-50, 2003 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-12711635
10.
Interferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines.
J Hematol Oncol
; 7: 7, 2014 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24418325
11.
Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways.
Mol Cancer Ther
; 13(6): 1625-35, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24672057
12.
Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.
Cancer Res
; 73(1): 225-34, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23100467
13.
Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib.
Cancer Res
; 70(11): 4318-26, 2010 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20460535
14.
MEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome.
Biochem J
; 373(Pt 1): 71-9, 2003 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12650640
15.
Group-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal-regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways.
J Neurochem
; 83(5): 1139-53, 2002 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-12437585
16.
Growth inhibition by the muscarinic M(3) acetylcholine receptor: evidence for p21(Cip1/Waf1) involvement in G(1) arrest.
Biochem J
; 367(Pt 2): 549-59, 2002 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12126481
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