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1.
Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization.
BMC Musculoskelet Disord
; 15: 291, 2014 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25185887
2.
Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases.
J Med Chem
; 67(11): 8545-8568, 2024 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38805213
3.
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
J Med Chem
; 64(6): 2937-2952, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33719441
4.
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
J Med Chem
; 63(22): 13526-13545, 2020 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32902984
5.
A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.
J Clin Invest
; 116(6): 1525-34, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16680194
6.
Population Pharmacokinetic and Pharmacodynamic Analysis of GLPG1690, an Autotaxin Inhibitor, in Healthy Volunteers and Patients with Idiopathic Pulmonary Fibrosis.
Clin Pharmacokinet
; 58(9): 1175-1191, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30953319
7.
Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 60(9): 3580-3590, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28414242
8.
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
J Med Chem
; 57(23): 10044-57, 2014 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25380412
9.
Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator.
J Med Chem
; 55(19): 8236-47, 2012 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-22957947
10.
Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer.
Neoplasia
; 13(6): 516-25, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21677875
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