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1.
The McCAVE Trial: Vanucizumab plus mFOLFOX-6 Versus Bevacizumab plus mFOLFOX-6 in Patients with Previously Untreated Metastatic Colorectal Carcinoma (mCRC).
Oncologist
; 25(3): e451-e459, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32162804
2.
Optimizing Early Clinical Investigations in Cancer Immunotherapy: The Translational Journey of RG6292, a Novel, Selective Treg-Depleting Antibody.
Clin Pharmacol Ther
; 2024 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38769868
3.
Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity from a Phase I Study of Simlukafusp Alfa (FAP-IL2v) in Advanced/Metastatic Solid Tumors.
Clin Cancer Res
; 2024 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38630781
4.
Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors.
Clin Cancer Res
; 30(8): 1630-1641, 2024 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38319672
5.
Phase II study to determine the anti-tumor activity and safety of simlukafusp alfa (FAP-IL2v) combined with atezolizumab in esophageal cancer.
Clin Cancer Res
; 2024 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38709220
6.
Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies.
J Immunother Cancer
; 9(7)2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34326166
7.
CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity.
Nat Cancer
; 1(12): 1153-1166, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33644766
8.
Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy.
Clin Cancer Res
; 24(14): 3325-3333, 2018 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29463551
9.
First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors.
Clin Cancer Res
; 24(7): 1536-1545, 2018 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29217526
10.
Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.
Clin Pharmacokinet
; 55(2): 237-47, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26341813
11.
Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers.
Psychopharmacology (Berl)
; 233(13): 2429-39, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27178435
12.
Physiologically based absorption modelling to predict the impact of drug properties on pharmacokinetics of bitopertin.
AAPS J
; 16(5): 1077-84, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24970349
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