Detalles de la búsqueda
1.
Targeting Lewy body dementia with neflamapimod-rasagiline hybrids.
Arch Pharm (Weinheim)
; 357(6): e2300525, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38412454
2.
From combinations to multitarget-directed ligands: A continuum in Alzheimer's disease polypharmacology.
Med Res Rev
; 41(5): 2606-2633, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32557696
3.
Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities.
Med Res Rev
; 40(6): 2177-2211, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32588916
4.
Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures.
Org Biomol Chem
; 18(42): 8526-8571, 2020 11 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33043327
5.
Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases.
Curr Top Med Chem
; 19(19): 1694-1711, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31237210
6.
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Eur J Med Chem
; 181: 111550, 2019 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31376562
7.
The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing.
Front Chem
; 6: 130, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29725591
8.
Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease.
Front Aging Neurosci
; 9: 175, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28638339
9.
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.
Eur J Med Chem
; 138: 761-773, 2017 Sep 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-28728108
10.
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration.
Mini Rev Med Chem
; 6(11): 1269-74, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17100639
11.
Rational approach to discover multipotent anti-Alzheimer drugs.
J Med Chem
; 48(2): 360-3, 2005 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-15658850
12.
Presynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus.
Brain Res
; 1629: 260-9, 2015 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26505913
13.
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3ß Fragment Hits against Alzheimer's Disease.
ACS Chem Neurosci
; 6(10): 1665-82, 2015 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-26171616
14.
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms.
J Med Chem
; 45(9): 1860-78, 2002 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-11960498
15.
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.
J Med Chem
; 46(23): 4895-903, 2003 Nov 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-14584940
16.
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.
J Med Chem
; 45(15): 3286-95, 2002 Jul 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-12109912
17.
Sequential virtual screening approach to the identification of small organic molecules as potential BACE-1 inhibitors.
Chem Biol Drug Des
; 77(4): 268-71, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21244641
18.
Alzheimer's disease: new approaches to drug discovery.
Curr Opin Chem Biol
; 13(3): 303-8, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19467915
19.
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
J Med Chem
; 51(15): 4381-4, 2008 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-18605718
20.
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents.
Curr Top Med Chem
; 7(2): 147-62, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17266603