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1.
Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.
Appl Environ Microbiol
; 77(19): 6982-90, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21821762
2.
Probing the structure-function relationship of polyene macrolides: engineered biosynthesis of soluble nystatin analogues.
J Med Chem
; 49(8): 2431-9, 2006 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-16610786
3.
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling.
BMC Syst Biol
; 7: 19, 2013 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23497367
4.
Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.
Appl Environ Microbiol
; 73(22): 7400-7, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17905880
5.
Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis.
Arch Microbiol
; 185(3): 165-71, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16416127
6.
Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.
Antimicrob Agents Chemother
; 49(11): 4576-83, 2005 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-16251298
7.
Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei.
J Biol Chem
; 278(17): 14913-9, 2003 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-12594224
8.
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
Antimicrob Agents Chemother
; 48(11): 4120-9, 2004 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-15504830
9.
In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis.
J Bacteriol
; 186(5): 1345-54, 2004 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-14973031
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