Detalles de la búsqueda
1.
Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists.
Bioorg Med Chem Lett
; 35: 127778, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33422603
2.
Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists.
Bioorg Med Chem Lett
; 30(12): 127204, 2020 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32334911
3.
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg Med Chem Lett
; 28(2): 85-93, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29233651
4.
Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.
J Immunol
; 192(9): 4083-92, 2014 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24670803
5.
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
J Pharmacol Exp Ther
; 354(2): 152-65, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26015463
6.
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.
ACS Med Chem Lett
; 11(6): 1221-1227, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551004
7.
A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo.
Angiogenesis
; 12(3): 287-96, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19544081
8.
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.
ACS Med Chem Lett
; 10(3): 367-373, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891142
9.
Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
J Med Chem
; 62(21): 9931-9946, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31638797
10.
Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.
J Med Chem
; 62(5): 2265-2285, 2019 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30785748
11.
Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.
Mol Pharmacol
; 73(2): 338-48, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17975007
12.
Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.
Mol Cancer Ther
; 5(10): 2459-67, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17041089
13.
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
J Med Chem
; 59(13): 6248-64, 2016 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27309907
14.
Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.
J Med Chem
; 59(24): 11138-11147, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28002964
15.
Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.
J Control Release
; 110(1): 90-102, 2005 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-16271793
16.
Anticancer drug delivery systems: multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C. II. Efficacy in ascites and solid tumors.
J Control Release
; 79(1-3): 55-70, 2002 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-11853918
17.
Delivery of G3139 using releasable PEG-linkers: impact on pharmacokinetic profile and anti-tumor efficacy.
J Control Release
; 119(2): 143-52, 2007 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17397960
18.
Engineering an arginine catabolizing bioconjugate: Biochemical and pharmacological characterization of PEGylated derivatives of arginine deiminase from Mycoplasma arthritidis.
Bioconjug Chem
; 17(6): 1447-59, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-17105223
19.
Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.
Bioconjug Chem
; 17(3): 618-30, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16704199
20.
Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation.
Protein Eng
; 16(10): 761-70, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-14600206
Resultados
1 -
20
de 20
1
Próxima >
>>