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1.
From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.
Bioorg Med Chem Lett
; 22(8): 2963-7, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22386529
2.
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
J Invest Dermatol
; 141(9): 2272-2279, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33744298
3.
Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.
Endocrinology
; 149(10): 5128-35, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18566121
4.
Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity.
Bioorg Med Chem
; 16(11): 6218-32, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18467104
5.
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors.
ACS Med Chem Lett
; 7(4): 379-84, 2016 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27096045
6.
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.
J Med Chem
; 58(18): 7140-63, 2015 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26090771
7.
Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment.
Biochem Pharmacol
; 67(12): 2281-9, 2004 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15163559
8.
Discovery and characterization of small molecule inhibitors of the BET family bromodomains.
J Med Chem
; 54(11): 3827-38, 2011 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-21568322
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