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1.
A novel synthetic analogue of ω-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells.
FASEB J
; 31(12): 5246-5257, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28798154
2.
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Nat Genet
; 39(9): 1074-82, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17676041
3.
The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU.
Int J Biochem Cell Biol
; 171: 106571, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38608921
4.
Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids.
Eur J Pharmacol
; 939: 175470, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36543287
5.
Preclinical Evaluation of Ixabepilone in Combination with VEGF Receptor and PARP Inhibitors in Taxane-Sensitive and Taxane-Resistant MDA-MB-231 Breast Cancer Cells.
J Pharm Sci
; 111(8): 2180-2190, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35700798
6.
The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells.
Pharmacol Rep
; 74(5): 998-1010, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35908023
7.
The aryl-ureido fatty acid CTU activates endoplasmic reticulum stress and PERK/NOXA-mediated apoptosis in tumor cells by a dual mitochondrial-targeting mechanism.
Cancer Lett
; 526: 131-141, 2022 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34822928
8.
PTU, a novel ureido-fatty acid, inhibits MDA-MB-231 cell invasion and dissemination by modulating Wnt5a secretion and cytoskeletal signaling.
Biochem Pharmacol
; 192: 114726, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34389322
9.
Carbon Chain Length Modulates MDA-MB-231 Breast Cancer Cell Killing Mechanisms by Mitochondrially Targeted Aryl-Urea Fatty Acids.
ChemMedChem
; 15(2): 247-255, 2020 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31773850
10.
Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter.
Chem Sci
; 11(47): 12677-12685, 2020 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-34094462
11.
Aryl-urea fatty acids that activate the p38 MAP kinase and down-regulate multiple cyclins decrease the viability of MDA-MB-231 breast cancer cells.
Eur J Pharm Sci
; 129: 87-98, 2019 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30597206
12.
Carboxylate Analogues of Aryl-Urea-Substituted Fatty Acids That Target the Mitochondria in MDA-MB-231 Breast Cancer Cells to Promote Cell Death.
ChemMedChem
; 13(10): 1036-1043, 2018 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29603659
13.
Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species.
Biochem Pharmacol
; 143: 79-89, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28756208
14.
A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin To Promote Killing of Breast Cancer Cells.
J Med Chem
; 60(20): 8661-8666, 2017 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-28921987
15.
Synthetic ω-3 epoxyfatty acids as antiproliferative and pro-apoptotic agents in human breast cancer cells.
J Med Chem
; 57(17): 7459-64, 2014 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25144895
16.
Anti-proliferative actions of N'-desmethylsorafenib in human breast cancer cells.
Biochem Pharmacol
; 86(3): 419-27, 2013 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23732299
17.
Antiproliferative and antimigratory actions of synthetic long chain n-3 monounsaturated fatty acids in breast cancer cells that overexpress cyclooxygenase-2.
J Med Chem
; 55(16): 7163-72, 2012 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-22822908
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