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1.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res
; : 1-7, 2023 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37362320
2.
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Bioorg Med Chem
; 25(20): 5490-5505, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28818462
3.
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Bioorg Med Chem
; 25(2): 496-513, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27914948
4.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther
; 358(3): 371-86, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27411717
5.
Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.
Bioorg Med Chem Lett
; 23(22): 6188-91, 2013 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24070783
6.
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4534-4564, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35261239
7.
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4457-4480, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35257579
8.
Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Bioorg Med Chem Lett
; 20(3): 1272-7, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20036536
9.
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 62(2): 831-856, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30576602
10.
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 60(6): 2513-2525, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28234467
11.
Soluble Abeta and cognitive function in aged F-344 rats and Tg2576 mice.
Behav Brain Res
; 173(1): 62-75, 2006 Oct 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-16828889
12.
Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy.
Exp Clin Psychopharmacol
; 14(1): 42-51, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16503704
13.
Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats.
Psychopharmacology (Berl)
; 231(4): 673-83, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24057763
14.
Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.
PLoS One
; 9(8): e106050, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25153994
15.
Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 62(4): 2213, 2019 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30734560
16.
Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease.
Psychopharmacology (Berl)
; 230(2): 279-89, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23783773
17.
Novel inhibitors of fatty acid amide hydrolase.
Bioorg Med Chem Lett
; 17(12): 3287-91, 2007 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17459705
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