Detalles de la búsqueda
1.
4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.
J Med Chem
; 48(2): 614-21, 2005 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-15658874
2.
3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.
J Med Chem
; 48(15): 4990-5000, 2005 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-16033278
3.
Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.
J Med Chem
; 48(10): 3492-503, 2005 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15887958
4.
Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.
J Med Chem
; 46(15): 3342-53, 2003 Jul 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-12852765
5.
1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action.
J Med Chem
; 56(8): 3247-56, 2013 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-23517501
6.
Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
J Med Chem
; 54(9): 3188-99, 2011 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-21428460
7.
2-alkyl-3-Alkylamino-2H-Benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?
Biol Chem
; 383(11): 1759-68, 2002 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12530541
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