Detalles de la búsqueda
1.
Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.
Mol Pharm
; 12(11): 3986-98, 2015 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-26393951
2.
Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei.
Toxicol Appl Pharmacol
; 269(1): 1-7, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23466428
3.
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg Med Chem Lett
; 23(7): 2181-6, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23465612
4.
Novel cinnoline-based inhibitors of LRRK2 kinase activity.
Bioorg Med Chem Lett
; 23(1): 71-4, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23219325
5.
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Bioorg Med Chem Lett
; 23(10): 3075-80, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23570791
6.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Bioorg Med Chem Lett
; 23(16): 4674-9, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23856050
7.
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett
; 23(9): 2743-9, 2013 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23522834
8.
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg Med Chem Lett
; 21(6): 1838-43, 2011 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21316234
9.
Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Bioorg Med Chem Lett
; 21(19): 5791-4, 2011 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21885276
10.
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorg Med Chem Lett
; 21(18): 5521-7, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21813278
11.
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Bioorg Med Chem Lett
; 21(1): 315-9, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21112785
12.
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Bioorg Med Chem Lett
; 20(24): 7303-7, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21071223
13.
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Bioorg Med Chem Lett
; 20(21): 6231-6, 2010 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20833041
14.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Bioorg Med Chem Lett
; 20(20): 6034-9, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20822903
15.
N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Bioorg Med Chem Lett
; 19(24): 6952-6, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19879755
16.
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 19(17): 4920-3, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19660943
17.
Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).
J Med Chem
; 61(24): 11127-11143, 2018 12 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30380863
18.
Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-alpha-D-glucose.
Carbohydr Res
; 337(4): 297-304, 2002 Feb 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-11841810
19.
Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of isotopically labeled 2-epi-5-epi-valiolone analogs.
Carbohydr Res
; 338(20): 2075-82, 2003 Sep 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-14505874
20.
Biosynthesis of the cyclitol moiety of pyralomicin 1a in Nonomuraea spiralis MI178-34F18.
J Antibiot (Tokyo)
; 55(6): 578-84, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12195964