Detalles de la búsqueda
1.
SLN124, a GalNAc conjugated 19-mer siRNA targeting tmprss6, reduces plasma iron and increases hepcidin levels of healthy volunteers.
Am J Hematol
; 98(9): 1425-1435, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37497888
2.
Ensovibep, a SARS-CoV-2 antiviral designed ankyrin repeat protein, is safe and well tolerated in healthy volunteers: Results of a first-in-human, ascending single-dose Phase 1 study.
Br J Clin Pharmacol
; 89(7): 2295-2303, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37057679
3.
Pharmacokinetics, safety, tolerability, and immunogenicity of FKB238, a new biosimilar of bevacizumab, in healthy participants.
Int J Clin Pharmacol Ther
; 60(6): 280-290, 2022 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-35361328
4.
ONO-7684 a novel oral FXIa inhibitor: Safety, tolerability, pharmacokinetics and pharmacodynamics in a first-in-human study.
Br J Clin Pharmacol
; 87(8): 3177-3189, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33450079
5.
Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.
J Infect Dis
; 219(2): 177-185, 2019 01 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30053042
6.
Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.
Mol Ther
; 25(1): 71-78, 2017 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28129130
7.
Pharmacokinetics, safety, tolerability and immunogenicity of FKB327, a new biosimilar medicine of adalimumab/Humira, in healthy subjects.
Br J Clin Pharmacol
; 83(7): 1405-1415, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28133772
8.
Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660).
Br J Clin Pharmacol
; 83(12): 2813-2820, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28800383
9.
Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis.
Br J Clin Pharmacol
; 83(3): 466-475, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27704617
10.
Randomised trial of the effect of a gastrin/CCK2 receptor antagonist on esomeprazole-induced hypergastrinaemia: evidence against rebound hyperacidity.
Eur J Clin Pharmacol
; 73(2): 129-139, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-27796466
11.
Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects.
Br J Clin Pharmacol
; 79(5): 744-55, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25335860
12.
Gastric neuroendocrine tumors: prevalence in Europe, USA, and Japan, and rationale for treatment with a gastrin/CCK2 receptor antagonist.
Scand J Gastroenterol
; 50(5): 550-9, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25665655
13.
Pharmacokinetics, pharmacodynamics and food effect of LB30870, a novel direct thrombin inhibitor, after single oral doses in healthy men.
Xenobiotica
; 45(8): 663-71, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25673087
14.
Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects.
Br J Clin Pharmacol
; 78(3): 498-508, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24628035
15.
Netazepide, an Antagonist of Cholecystokinin Type 2 Receptor, Prevents Vincristine-Induced Sensory Neuropathy in Mice.
Pharmaceuticals (Basel)
; 17(2)2024 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38399359
16.
Effect of repeated doses of netazepide, a gastrin receptor antagonist, omeprazole and placebo on 24 h gastric acidity and gastrin in healthy subjects.
Br J Clin Pharmacol
; 76(5): 680-8, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23432415
17.
Netazepide, a gastrin/CCK2 receptor antagonist, causes dose-dependent, persistent inhibition of the responses to pentagastrin in healthy subjects.
Br J Clin Pharmacol
; 76(5): 689-98, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23432534
18.
Giving monoclonal antibodies to healthy volunteers in phase 1 trials: is it safe?
Br J Clin Pharmacol
; 76(2): 164-72, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23438102
19.
A novel assay to measure B cell responses to keyhole limpet haemocyanin vaccination in healthy volunteers and subjects with systemic lupus erythematosus.
Br J Clin Pharmacol
; 76(2): 188-202, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23731388
20.
The gastrin receptor antagonist netazepide (YF476) prevents oxyntic mucosal inflammation induced by Helicobacter pylori infection in Mongolian gerbils.
Helicobacter
; 18(6): 397-405, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23865485