Detalles de la búsqueda
1.
Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc Natl Acad Sci U S A
; 120(41): e2300258120, 2023 10 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37801475
2.
Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J Biol Chem
; 300(2): 105531, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38072051
3.
Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.
Proc Natl Acad Sci U S A
; 119(15): e2119952119, 2022 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35377792
4.
Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like ß-sheets.
J Biol Chem
; 298(10): 102396, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35988647
5.
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
Proc Natl Acad Sci U S A
; 117(7): 3592-3602, 2020 02 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-32015135
6.
Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
J Biol Chem
; 294(44): 16451-16464, 2019 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31537646
7.
DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity.
bioRxiv
; 2024 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36945632
8.
DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity.
Structure
; 32(6): 662-678.e8, 2024 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38508190
9.
How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism.
bioRxiv
; 2024 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-38585812
10.
Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method.
PNAS Nexus
; 2(12): pgad402, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38077690
11.
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.
Nat Commun
; 14(1): 2379, 2023 04 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37185252
12.
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun
; 13(1): 5451, 2022 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36114178
13.
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.
Nat Struct Mol Biol
; 28(9): 724-730, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34518699
14.
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
bioRxiv
; 2021 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33688654
15.
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.
Nat Struct Mol Biol
; 27(7): 653-659, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32541896
16.
CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun
; 11(1): 4090, 2020 08 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32796831
17.
Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
Nat Struct Mol Biol
; 26(7): 619-627, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31235914
18.
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat Struct Mol Biol
; 26(11): 1044-1052, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31695184
19.
Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat Struct Mol Biol
; 26(10): 988, 2019 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-31530939
20.
Structure of amyloid-ß (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun
; 10(1): 3357, 2019 07 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31350392