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1.
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Proc Natl Acad Sci U S A
; 118(3)2021 01 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33446504
2.
Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J Biol Chem
; 293(32): 12634-12646, 2018 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29794134
3.
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(23): 6447-54, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24139583
4.
Discovery of AM-6494: A Potent and Orally Efficacious ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.
J Med Chem
; 63(5): 2263-2281, 2020 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31589043
5.
Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Cancer Biol Ther
; 5(6): 657-64, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16627989
6.
Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.
Biochem Biophys Res Commun
; 299(4): 569-73, 2002 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-12459176
7.
Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression, fibrinogen binding, and microaggregate formation in a phase I dose-finding study: no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa antagonist.
Platelets
; 14(3): 179-87, 2003 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12850842
8.
Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated.
Blood
; 99(10): 3540-6, 2002 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-11986205
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