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1.
Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
J Immunol
; 197(6): 2421-33, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27521339
2.
A mechanistic pharmacodynamic model of IRAK-4 drug inhibition in the Toll-like receptor pathway.
J Pharmacokinet Pharmacodyn
; 40(5): 609-22, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24097307
3.
Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood.
J Transl Med
; 8: 51, 2010 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-20509950
4.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J Med Chem
; 60(13): 5521-5542, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28498658
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