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1.
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Nature
; 556(7702): 501-504, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29670287
2.
Effectiveness of COVID-19 mRNA Vaccination in Preventing COVID-19-Associated Hospitalization Among Adults with Previous SARS-CoV-2 Infection - United States, June 2021-February 2022.
MMWR Morb Mortal Wkly Rep
; 71(15): 549-555, 2022 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35421077
3.
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement.
Bioorg Med Chem Lett
; 27(15): 3477-3485, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28629594
4.
Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling.
Bioorg Med Chem
; 24(10): 2215-34, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27085672
5.
The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR.
Bioorg Med Chem Lett
; 22(5): 2033-42, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22306122
6.
2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors.
Bioorg Med Chem Lett
; 22(17): 5392-5, 2012 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22877629
7.
Corrigendum to "Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling" [Bioorg. Med. Chem. 24 (2016) 2215-2234].
Bioorg Med Chem
; 24(13): 3093, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27234892
8.
The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.
Biochemistry
; 48(23): 5187-98, 2009 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-19371126
9.
From imide to lactam metallo-pyridocarbazoles: distinct scaffolds for the design of selective protein kinase inhibitors.
J Org Chem
; 74(23): 8997-9009, 2009 Dec 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-19886617
10.
An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.
Cancer Res
; 67(1): 209-17, 2007 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17210701
11.
Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators.
Eur J Med Chem
; 137: 63-75, 2017 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28575722
12.
Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.
Nat Struct Mol Biol
; 24(2): 108-113, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27991902
13.
The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors.
J Med Chem
; 60(3): 1105-1125, 2017 02 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28001399
14.
Correction to "Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement".
ACS Med Chem Lett
; 8(3): 378, 2017 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28337335
15.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.
J Med Chem
; 60(14): 5969-5989, 2017 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28287723
16.
Ruthenium half-sandwich complexes as protein kinase inhibitors: an N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety.
Org Lett
; 8(24): 5465-8, 2006 Nov 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-17107048
17.
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.
J Med Chem
; 59(17): 7818-39, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27441383
18.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement.
ACS Med Chem Lett
; 7(12): 1062-1067, 2016 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27994738
19.
Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain.
PLoS One
; 10(9): e0138140, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26379236
20.
Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket.
J Med Chem
; 56(3): 1341-5, 2013 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23316926