Detalles de la búsqueda
1.
Enzymatic activity of Lecithin:retinol acyltransferase: a thermostable and highly active enzyme with a likely mode of interfacial activation.
Biochim Biophys Acta
; 1844(6): 1128-36, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24613493
2.
Secondary structure of a truncated form of lecithin retinol acyltransferase in solution and evidence for its binding and hydrolytic action in monolayers.
Biochim Biophys Acta
; 1778(5): 1324-34, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18284914
3.
Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition.
Biochemistry
; 47(51): 13537-46, 2008 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-19075558
4.
The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.
Biochemistry
; 47(32): 8261-70, 2008 Aug 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-18624455
5.
Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.
J Mol Biol
; 369(2): 525-40, 2007 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17442338
6.
Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.
J Mol Biol
; 364(4): 747-63, 2006 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-17034817
7.
Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci
; 15(5): 987-99, 2006 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-16641486
8.
Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.
Protein Sci
; 14(6): 1485-97, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15929998
9.
Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2.
Biochim Biophys Acta
; 1679(3): 230-47, 2004 Sep 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15358515
10.
Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
J Mol Biol
; 339(1): 89-102, 2004 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15123423
11.
Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.
J Mol Biol
; 331(3): 593-604, 2003 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12899831
12.
Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.
BMC Biochem
; 6: 12, 2005 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-16018803
13.
Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens.
Bioorg Med Chem
; 15(8): 3003-18, 2007 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17336533
14.
Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12.
J Biol Chem
; 282(42): 30910-9, 2007 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17711855
15.
Binding of RPE65 fragments to lipid monolayers and identification of its partners by glutathione S-transferase pull-down assays.
Biochemistry
; 45(10): 3337-47, 2006 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-16519528
16.
The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents.
Biochem Biophys Res Commun
; 310(3): 767-73, 2003 Oct 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-14550269
17.
Expression, crystallization and preliminary X-ray analysis of human and rabbit 20alpha-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates.
Acta Crystallogr D Biol Crystallogr
; 58(Pt 1): 135-9, 2002 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-11752791
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