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1.
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
J Med Chem
; 63(2): 512-528, 2020 01 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31721572
2.
Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.
J Med Chem
; 58(1): 376-400, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25402320
3.
Discovery and optimization of pyrimidone indoline amide PI3Kß inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers.
J Med Chem
; 57(3): 903-20, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24387221
4.
Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase.
Bioorg Med Chem Lett
; 14(24): 6053-6, 2004 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-15546728
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