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1.
A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation.
Bioorg Med Chem Lett
; 29(9): 1074-1078, 2019 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30857747
2.
Azetidine ring, salicylic acid, and salicylic acid bioisosteres as determinants of the binding characteristics of novel potent compounds to Stat3.
Bioorg Med Chem Lett
; 97: 129565, 2024 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38008341
3.
Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo.
Cancer Lett
; 534: 215613, 2022 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35276290
4.
Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.
J Med Chem
; 64(1): 695-710, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33352047
5.
Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorg Med Chem Lett
; 20(14): 4215-8, 2010 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20538456
6.
Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist.
Bioorg Med Chem Lett
; 20(3): 1031-6, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20045645
7.
Spiropiperidine CCR5 antagonists.
Bioorg Med Chem Lett
; 19(18): 5401-6, 2009 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19674898
8.
Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.
ACS Med Chem Lett
; 9(3): 250-255, 2018 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29541369
9.
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
J Med Chem
; 61(8): 3641-3659, 2018 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29590749
10.
Novel Series of Dihydropyridinone P2X7 Receptor Antagonists.
J Med Chem
; 58(21): 8413-26, 2015 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-26460788
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