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1.
The indigoidine synthetase BpsA provides a colorimetric ATP assay that can be adapted to quantify the substrate preferences of other NRPS enzymes.
Biotechnol Lett
; 42(12): 2665-2671, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32681380
2.
High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor.
Molecules
; 25(20)2020 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33066278
3.
Structural, functional and evolutionary perspectives on effective re-engineering of non-ribosomal peptide synthetase assembly lines.
Nat Prod Rep
; 35(11): 1210-1228, 2018 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30069573
4.
Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein.
J Struct Biol
; 188(3): 274-8, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25450595
5.
Directed Evolution of the BpsA Carrier Protein Domain for Recognition by Non-cognate 4'-Phosphopantetheinyl Transferases to Enable Inhibitor Screening.
Methods Mol Biol
; 2670: 145-163, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37184703
6.
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
bioRxiv
; 2023 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-36993673
7.
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Cell Chem Biol
; 30(12): 1680-1691.e6, 2023 12 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-37898120
8.
Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT.
Pharmaceutics
; 13(7)2021 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34371757
9.
Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates.
ACS Infect Dis
; 6(11): 2879-2886, 2020 11 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33118808
10.
Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections.
mBio
; 11(5)2020 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32934086
11.
Bioactivity-Guided Metabolite Profiling of Feijoa ( Acca sellowiana) Cultivars Identifies 4-Cyclopentene-1,3-dione as a Potent Antifungal Inhibitor of Chitin Synthesis.
J Agric Food Chem
; 66(22): 5531-5539, 2018 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29546758
12.
A sensitive single-enzyme assay system using the non-ribosomal peptide synthetase BpsA for measurement of L-glutamine in biological samples.
Sci Rep
; 7: 41745, 2017 01 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-28139746
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