Detalles de la búsqueda
1.
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-ß pathology.
Cell Mol Life Sci
; 80(7): 178, 2023 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37306762
2.
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Brain Behav Immun
; 109: 1-22, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36584795
3.
Novel insights on the molecular mechanism of action of the anti-angiogenic pyrazolyl-urea GeGe-3 by functional proteomics.
Bioorg Chem
; 115: 105168, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34284173
4.
New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways.
Molecules
; 26(19)2021 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34641279
5.
Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry.
Molecules
; 25(15)2020 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-32751358
6.
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets.
Molecules
; 25(4)2020 Feb 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-32085423
7.
Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition.
Molecules
; 25(4)2020 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-32093112
8.
Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry
; 57(19): 2876-2888, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29652483
9.
Design and synthesis of 4,5,6,7-tetrahydro-1H-1,2-diazepin-7-one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors.
Bioorg Med Chem Lett
; 27(1): 24-29, 2017 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27890378
10.
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles.
J Enzyme Inhib Med Chem
; 32(1): 375-402, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28276287
11.
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies.
Mol Divers
; 20(1): 77-92, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26290462
12.
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.
Ann Neurol
; 75(4): 602-7, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24591104
13.
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors.
Bioorg Med Chem
; 23(13): 3426-35, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25936260
14.
Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition.
Neurotherapeutics
; : e00372, 2024 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38760316
15.
Phosphodiesterase isoform-specific expression induced by traumatic brain injury.
J Neurochem
; 123(6): 1019-29, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23057870
16.
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation.
Bioorg Med Chem Lett
; 22(2): 1125-9, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22189137
17.
Docking-based CoMFA and CoMSIA analyses of tetrahydro-ß-carboline derivatives as type-5 phosphodiesterase inhibitors.
J Enzyme Inhib Med Chem
; 27(5): 730-43, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22014072
18.
The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs.
Biomolecules
; 11(12)2021 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34944403
19.
Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors.
Eur J Med Chem
; 223: 113638, 2021 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34171658
20.
Synthesis, functional proteomics and biological evaluation of new 5-pyrazolyl ureas as potential anti-angiogenic compounds.
Eur J Med Chem
; 226: 113872, 2021 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34600191