Detalles de la búsqueda
1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37125593
2.
Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter ß-amyloid levels in the CNS.
J Neurochem
; 132(4): 477-86, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25156639
3.
Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.
J Biol Chem
; 287(49): 41245-57, 2012 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-23048024
4.
Effect of solvents on the time-dependent inhibition of CYP3A4 and the biotransformation of AZD3839 in human liver microsomes and hepatocytes.
Drug Metab Dispos
; 41(1): 159-69, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23073735
5.
Biotransformation of two ß-secretase inhibitors including ring opening and contraction of a pyrimidine ring.
Drug Metab Dispos
; 41(5): 1134-47, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23474650
6.
In vivo and ex vivo inhibition of spinal nerve ligation-induced ectopic activity by sodium channel blockers correlate to in vitro inhibition of NaV1.7 and clinical efficacy: a pharmacokinetic-pharmacodynamic translational approach.
Pharm Res
; 30(5): 1409-22, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23371514
7.
Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human.
Xenobiotica
; 43(7): 607-16, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23278250
8.
Novel bioactivation mechanism of reactive metabolite formation from phenyl methyl-isoxazoles.
Drug Metab Dispos
; 40(11): 2185-91, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22908203
9.
Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers.
Bioorg Med Chem Lett
; 22(17): 5618-24, 2012 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22832315
10.
Phenethyl nicotinamides, a novel class of Na(V)1.7 channel blockers: structure and activity relationship.
Bioorg Med Chem Lett
; 22(19): 6108-15, 2012 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22939696
11.
The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease.
Sci Transl Med
; 14(627): eabg3684, 2022 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35020407
12.
Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.
Bioorg Med Chem Lett
; 21(13): 3871-6, 2011 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21641215
13.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34704436
14.
Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.
J Med Chem
; 63(5): 2411-2425, 2020 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32101422
15.
Assessment of translational risk in drug research: Role of biomarker classification and mechanism-based PKPD concepts.
Eur J Pharm Sci
; 109S: S72-S77, 2017 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28811131
16.
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
J Med Chem
; 60(16): 6771-6780, 2017 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-28418656
17.
Profound but transient deficits in learning and memory after global ischemia using a novel water maze test.
Behav Brain Res
; 166(2): 204-10, 2006 Jan 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-16159675
18.
Optimizing DMPK Properties: Experiences from a Big Pharma DMPK Department.
Curr Drug Metab
; 17(3): 253-70, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26651977
19.
Reappearance of hippocampal CA1 neurons after ischemia is associated with recovery of learning and memory.
J Cereb Blood Flow Metab
; 25(12): 1586-95, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15917746
20.
Reproducible loss of CA1 neurons following carotid artery occlusion combined with halothane-induced hypotension.
Brain Res
; 1033(2): 135-42, 2005 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-15694917