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1.
Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients.
Br J Clin Pharmacol
; 81(1): 89-100, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26317320
2.
Pharmacokinetics, metabolism and excretion of [(14)C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects.
Xenobiotica
; 45(3): 244-55, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25259653
3.
Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents.
Biopharm Drug Dispos
; 35(6): 341-52, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24797229
4.
The right compound in the right assay at the right time: an integrated discovery DMPK strategy.
Drug Metab Rev
; 44(3): 224-52, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22697420
5.
4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: identifying clinical candidates.
Bioorg Med Chem Lett
; 22(2): 1174-8, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22197137
6.
Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications.
Bioorg Med Chem Lett
; 22(2): 1169-73, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22197139
7.
In vitro and in vivo metabolism of a selective δ-opioid receptor.
Drug Metab Dispos
; 39(10): 1883-94, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21752944
8.
Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.
Clin Pharmacol Ther
; 104(1): 188-200, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29027194
9.
Population Exposure-Response Modeling Supported Selection of Naloxegol Doses in Phase III Studies in Patients With Opioid-Induced Constipation.
CPT Pharmacometrics Syst Pharmacol
; 6(10): 705-711, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28782266
10.
Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study.
Neuropsychopharmacology
; 42(4): 844-853, 2017 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-27681442
11.
Population pharmacokinetic modeling of quetiapine after administration of seroquel and seroquel XR formulations to Western and Chinese patients with schizophrenia, schizoaffective disorder, or bipolar disorder.
J Clin Pharmacol
; 55(11): 1248-55, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25975812
12.
Effect of multiple intravenous doses of lanicemine (AZD6765) on the pharmacokinetics of midazolam in healthy subjects.
J Clin Pharmacol
; 55(9): 1024-30, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25880724
13.
Combining radio telemetry and automated blood sampling: a novel approach for integrative pharmacology and toxicology studies.
J Pharmacol Toxicol Methods
; 62(1): 30-9, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20507819
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