Detalles de la búsqueda
1.
In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs.
Biol Chem
; 404(4): 255-265, 2023 03 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36427206
2.
Transition Metal-Free Synthesis of meta-Bromo- and meta-Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction.
Chemistry
; 28(10): e202102998, 2022 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35076996
3.
Synthesis of Polysubstituted Meta-Halophenols by Anion-Accelerated 2π-Electrocyclic Ring Opening.
Chemistry
; 27(42): 10941-10947, 2021 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34041800
4.
A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude).
Mol Pharmacol
; 88(2): 401-20, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26056160
5.
The glutamate transport inhibitor DL-Threo-ß-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.
BMC Cancer
; 15: 411, 2015 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-25981639
6.
Blood-brain barrier permeability and brain uptake mechanism of kainic acid and dihydrokainic acid.
Neurochem Res
; 40(3): 542-9, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25488153
7.
Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.
J Neurosci
; 33(3): 1068-87, 2013 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-23325245
8.
Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs.
Neurochem Res
; 39(10): 1964-79, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24682739
9.
Profiling substrate specificity of two series of phenethylamine analogs at monoamine oxidase A and B.
Org Biomol Chem
; 12(43): 8689-95, 2014 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-25253656
10.
Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist.
J Med Chem
; 67(2): 1314-1326, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38170918
11.
Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists.
Eur J Med Chem
; 266: 116157, 2024 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38245976
12.
Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.
J Struct Biol
; 180(1): 39-46, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22789682
13.
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.
Bioorg Med Chem
; 20(23): 6831-9, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23072958
14.
Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity.
Front Chem
; 10: 1008233, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36465862
15.
Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity.
J Med Chem
; 65(1): 734-746, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34918931
16.
(S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist.
ACS Chem Neurosci
; 13(10): 1580-1587, 2022 05 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-35475632
17.
Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate.
J Struct Biol
; 176(3): 307-14, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21907808
18.
ß-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs).
ACS Med Chem Lett
; 11(11): 2212-2220, 2020 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214831
19.
From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors.
ACS Chem Neurosci
; 11(24): 4362-4375, 2020 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-33170625
20.
Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT2A/mGlu2 Receptor Complex.
J Med Chem
; 63(17): 9928-9949, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32815361