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1.
Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis.
Environ Sci Technol
; 54(1): 335-344, 2020 01 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31752483
2.
Lifetime extension of humpback whale skin fibroblasts and their response to lipopolysaccharide (LPS) and a mixture of polychlorinated biphenyls (Aroclor).
Cell Biol Toxicol
; 35(4): 387-398, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30627956
3.
Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
Bioorg Med Chem Lett
; 24(11): 2477-80, 2014 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24780121
4.
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
Bioorg Med Chem Lett
; 24(12): 2635-9, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24813737
5.
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
J Med Chem
; 63(13): 6679-6693, 2020 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32250617
6.
The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Cancer Discov
; 10(1): 54-71, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31658955
7.
Hexachlorobenzene exerts genotoxic effects in a humpback whale cell line under stable exposure conditions.
RSC Adv
; 9(67): 39447-39457, 2019 Nov 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35540658
8.
Improving a fish intestinal barrier model by combining two rainbow trout cell lines: epithelial RTgutGC and fibroblastic RTgutF.
Cytotechnology
; : 835-848, 2019 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-31256301
9.
Microtiter plate bioassay to monitor the interference of antibiotics with the lipid II cycle essential for peptidoglycan biosynthesis.
J Microbiol Methods
; 75(1): 70-4, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18558445
10.
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
ACS Med Chem Lett
; 9(12): 1230-1234, 2018 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30613331
11.
Development and application of a microtiter plate-based autoinduction bioassay for detection of the lantibiotic subtilin.
J Microbiol Methods
; 70(1): 179-85, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17532072
12.
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.
J Med Chem
; 59(12): 5650-60, 2016 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27227380
13.
Establishment of the first humpback whale fibroblast cell lines and their application in chemical risk assessment.
Aquat Toxicol
; 167: 240-7, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26363275
14.
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.
J Med Chem
; 58(4): 1976-91, 2015 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25603482
15.
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.
J Med Chem
; 57(23): 10112-29, 2014 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25411915
16.
Emergence and Targeting of Acquired and Hereditary Resistance to Multikinase RET Inhibition in Patients With RET-Altered Cancer.
JCO Precis Oncol
; 32019.
Artículo
en Inglés
| MEDLINE | ID: mdl-32923848
17.
Discovery of 7-tetrahydropyran-2-yl chromans: ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid ß-protein (Aß) in the central nervous system.
J Med Chem
; 57(3): 878-902, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24397738
18.
Spirocyclic ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid ß in a higher species.
J Med Chem
; 56(8): 3379-403, 2013 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-23537249
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