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1.
In silico clinical trials for relapsing-remitting multiple sclerosis with MS TreatSim.
BMC Med Inform Decis Mak
; 22(Suppl 6): 294, 2022 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36380294
2.
Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.
Br J Clin Pharmacol
; 82(1): 92-107, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26924818
3.
Accelerating Digitalization in Healthcare with the InSilicoTrials Cloud-Based Platform: Four Use Cases.
Ann Biomed Eng
; 51(1): 125-136, 2023 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-36074307
4.
Moving forward through the in silico modeling of multiple sclerosis: Treatment layer implementation and validation.
Comput Struct Biotechnol J
; 21: 3081-3090, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37266405
5.
Design, synthesis and structure-activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate.
Bioorg Med Chem Lett
; 21(8): 2541-6, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21411321
6.
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.
CPT Pharmacometrics Syst Pharmacol
; 10(8): 804-825, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34102034
7.
Evaluation of the Population Pharmacokinetic Properties of Lidocaine and its Metabolites After Long-Term Multiple Applications of a Lidocaine Plaster in Post-Herpetic Neuralgia Patients.
Eur J Drug Metab Pharmacokinet
; 42(5): 801-814, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28078530
8.
Derivation and validation of toxicophores for mutagenicity prediction.
J Med Chem
; 48(1): 312-20, 2005 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-15634026
9.
Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.
CPT Pharmacometrics Syst Pharmacol
; 9(4): 195-197, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32237207
10.
A three-dimensional quantitative structure-activity relationship study of heparin-binding epidermal growth factor shedding inhibitors using comparative molecular field analysis.
J Med Chem
; 45(4): 781-8, 2002 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11831891
11.
Structure-activity relationship study of human liver microsomes-catalyzed hydrolysis rate of ester prodrugs of MENT by comparative molecular field analysis (CoMFA).
Steroids
; 68(3): 213-20, 2003 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-12628684
12.
Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection.
Drugs R D
; 12(3): 127-39, 2012 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22852579
13.
Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial.
J Psychopharmacol
; 26(12): 1525-39, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22954616
14.
Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576.
Psychopharmacology (Berl)
; 218(4): 713-24, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21647578
15.
The binding mode of progesterone to its receptor deduced from molecular dynamics simulations.
Chembiochem
; 4(2-3): 155-61, 2003 Mar 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-12616628
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