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1.
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury.
Angew Chem Int Ed Engl
; 63(14): e202316496, 2024 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38348945
2.
Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates for human ornithine aminotransferase.
J Biol Chem
; 298(6): 101969, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35460691
3.
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid.
Molecules
; 28(3)2023 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36770800
4.
Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.
J Am Chem Soc
; 144(12): 5629-5642, 2022 03 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35293728
5.
Perturbing the Movement of Hydrogens to Delineate and Assign Events in the Reductive Activation and Turnover of Porcine Dihydropyrimidine Dehydrogenase.
Biochemistry
; 60(22): 1764-1775, 2021 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34032117
6.
The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil.
Biochemistry
; 60(14): 1120-1132, 2021 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33755421
7.
Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
J Am Chem Soc
; 143(21): 8193-8207, 2021 06 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34014654
8.
Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase.
J Am Chem Soc
; 143(23): 8689-8703, 2021 06 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-34097381
9.
A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid.
J Am Chem Soc
; 142(10): 4892-4903, 2020 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32114761
10.
Correction to "Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase".
J Am Chem Soc
; 145(17): 9895-9896, 2023 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37075548
11.
Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF3).
ACS Chem Biol
; 16(1): 67-75, 2021 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33316155
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