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1.
ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer.
BMC Cancer
; 22(1): 1107, 2022 Oct 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36309653
2.
Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.
Br J Cancer
; 123(9): 1424-1436, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32741974
3.
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.
Br J Cancer
; 119(10): 1233-1243, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30385821
4.
Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease.
Am J Respir Crit Care Med
; 185(1): 34-43, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21997333
5.
Relevance of ATM Status in Driving Sensitivity to DNA Damage Response Inhibitors in Patient-Derived Xenograft Models.
Cancers (Basel)
; 15(16)2023 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-37627223
6.
Simultaneous inhibition of DNA-PK and PolÏ´ improves integration efficiency and precision of genome editing.
Nat Commun
; 14(1): 4761, 2023 08 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37580318
7.
The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.
Mol Cancer Ther
; 21(4): 555-567, 2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35149547
8.
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.
ACS Med Chem Lett
; 13(8): 1295-1301, 2022 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35978693
9.
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.
Clin Cancer Res
; 27(15): 4353-4366, 2021 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34011558
10.
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically.
Mol Cancer Ther
; 19(1): 13-25, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31534013
11.
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
J Med Chem
; 63(7): 3461-3471, 2020 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31851518
12.
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.
Nat Commun
; 10(1): 5065, 2019 11 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31699977
13.
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Mol Cancer Ther
; 17(8): 1637-1647, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29769307
14.
The novel ATM inhibitor (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan monotherapy.
Oncotarget
; 8(67): 110904-110913, 2017 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-29340025
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