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1.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.
Bioorg Med Chem Lett
; 22(12): 3946-50, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22608961
2.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Bioorg Med Chem Lett
; 22(12): 3951-6, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22608393
3.
Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.
Bioorg Med Chem Lett
; 20(9): 2998-3002, 2010 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20382527
4.
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215).
J Med Chem
; 51(6): 1976-80, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18288793
5.
Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors.
Bioorg Med Chem Lett
; 18(4): 1354-8, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18221875
6.
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors.
Bioorg Med Chem Lett
; 18(11): 3224-9, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18479916
7.
Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.
Bioorg Med Chem Lett
; 18(6): 1945-51, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18289854
8.
Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.
Bioorg Med Chem Lett
; 18(9): 2985-9, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18395443
9.
Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.
J Med Chem
; 49(7): 2143-6, 2006 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16570908
10.
Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitors.
J Med Chem
; 48(12): 3991-4008, 2005 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15943473
11.
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
J Med Chem
; 45(18): 3905-27, 2002 Aug 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-12190313
12.
The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases.
Mol Cancer Ther
; 9(2): 369-78, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20103604
13.
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.
J Med Chem
; 52(5): 1251-4, 2009 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-19260711
14.
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.
J Med Chem
; 51(17): 5330-41, 2008 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-18690676
15.
Addition of benzylic and allylic organozinc and Grignard reagents to resin-bound imines to provide alpha-branched secondary amines bearing a wide variety of functional groups. Utility in the synthesis of beta-3 adrenergic receptor agonists.
J Comb Chem
; 7(1): 99-108, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-15638488
16.
Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors.
Bioorg Med Chem Lett
; 15(5): 1429-33, 2005 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15713401
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