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1.
Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats.
Toxicol Appl Pharmacol
; 475: 116627, 2023 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37453479
2.
Tpl2 kinase regulates inflammation but not tumorigenesis in mice.
Toxicol Appl Pharmacol
; 418: 115494, 2021 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33722668
3.
Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs.
Toxicol Pathol
; 48(3): 465-480, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32124659
4.
An Automated Image Analysis Method to Quantify Veterinary Bone Marrow Cellularity on H&E Sections.
Toxicol Pathol
; 46(3): 324-335, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29683091
5.
Proof of Concept for an Automated Image Analysis Method to Quantify Rat Bone Marrow Hematopoietic Lineages on H&E Sections.
Toxicol Pathol
; 46(3): 336-347, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29683092
6.
MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats.
Toxicol Pathol
; 45(2): 353-361, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27565173
7.
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
J Med Chem
; 67(5): 3287-3306, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38431835
8.
Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
Toxicol Appl Pharmacol
; 266(1): 86-94, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23142475
9.
Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors.
Xenobiotica
; 42(5): 456-65, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22122353
10.
Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function.
Am J Physiol Regul Integr Comp Physiol
; 298(3): R534-47, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20032263
11.
Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer.
PLoS One
; 13(6): e0198099, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29879147
12.
Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.
Sci Transl Med
; 10(468)2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30463918
13.
Assessment of placental transfer and the effect on embryo-fetal development of a humanized monoclonal antibody targeting lymphotoxin-alpha in non-human primates.
Reprod Toxicol
; 63: 82-95, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27211603
14.
Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation.
Clin Cancer Res
; 22(6): 1469-79, 2016 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26589434
15.
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window.
J Med Chem
; 59(11): 5520-41, 2016 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27167326
16.
Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit.
J Neurosci
; 24(24): 5537-48, 2004 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15201326
17.
Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.
Toxicol Sci
; 131(1): 247-58, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22956632
18.
Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG.
MAbs
; 5(4): 540-54, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23774668
19.
Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900.
Mol Cancer Ther
; 12(10): 1968-80, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23873850
20.
Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.
Toxicol Sci
; 125(1): 187-95, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21976371