Detalles de la búsqueda
1.
Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.
Bioorg Chem
; 147: 107383, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38653151
2.
Development and molecular modeling studies of new thiadiazole piperazine urea derivatives as potential fatty acid amide hydrolase inhibitors.
Arch Pharm (Weinheim)
; 355(8): e2200082, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-35500130
3.
Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy.
Bioorg Chem
; 112: 104861, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33826984
4.
Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors.
Bioorg Chem
; 95: 103544, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31915112
5.
Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents.
J Enzyme Inhib Med Chem
; 33(1): 1352-1361, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30251900
6.
Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer.
Cancer Res
; 84(9): 1475-1490, 2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38319231
7.
Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors.
ACS Omega
; 8(2): 2445-2454, 2023 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36687110
8.
Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification.
Cell Death Differ
; 30(5): 1305-1319, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36864125
9.
Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer.
bioRxiv
; 2023 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37745348
10.
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).
Bioorg Med Chem
; 20(12): 3728-41, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22607880
11.
Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors.
ChemMedChem
; 17(12): e202200137, 2022 06 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35466565
12.
Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition.
ACS Omega
; 7(41): 36354-36365, 2022 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36278102
13.
Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase.
Eur J Med Chem
; 231: 114167, 2022 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35152061
14.
Vicinal Diaryl-Substituted Isoxazole and Pyrazole Derivatives with In Vitro Growth Inhibitory and In Vivo Antitumor Activity.
ACS Omega
; 7(41): 36206-36226, 2022 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36278052
15.
Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells.
Eur J Med Chem
; 221: 113489, 2021 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33951549
16.
Antimigratory effect of pyrazole derivatives through the induction of STAT1 phosphorylation in A549 cancer cells.
J Pharm Pharmacol
; 73(6): 808-815, 2021 Apr 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33730148
17.
A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate.
Mol Cancer Ther
; 19(6): 1243-1254, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32217742
18.
HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches.
Exp Clin Transplant
; 17(6): 813-818, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28350290
19.
A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandinâ E2 Synthase-1 (mPGES-1) Inhibitors.
ChemMedChem
; 14(2): 273-281, 2019 01 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-30537167
20.
Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis.
Eur J Med Chem
; 153: 34-48, 2018 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28784429