Detalles de la búsqueda
1.
In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes.
Drug Metab Dispos
; 48(12): 1350-1363, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33020067
2.
Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model.
Chem Res Toxicol
; 33(1): 211-222, 2020 01 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31538772
3.
Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.
Mol Pharm
; 15(3): 1284-1295, 2018 03 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29433307
4.
The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.
Drug Metab Dispos
; 44(10): 1569-78, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27440861
5.
Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data.
Drug Metab Dispos
; 44(5): 781-91, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26956641
6.
Physiologically Based Pharmacokinetic Modeling of the Drug-Drug Interaction Between CYP3A4 Substrate Glasdegib and Moderate CYP3A4 Inducers in Lieu of a Clinical Study.
J Clin Pharmacol
; 64(1): 80-93, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37731282
7.
Drug metabolites as cytochrome p450 inhibitors: a retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development.
Drug Metab Dispos
; 41(12): 2047-55, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23792812
8.
Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects.
Drug Metab Dispos
; 41(2): 445-56, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23169609
9.
A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.
Br J Clin Pharmacol
; 72(2): 235-46, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21392072
10.
Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid.
CPT Pharmacometrics Syst Pharmacol
; 10(2): 127-136, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33314761
11.
End-to-end application of model-informed drug development for ertugliflozin, a novel sodium-glucose cotransporter 2 inhibitor.
CPT Pharmacometrics Syst Pharmacol
; 10(6): 529-542, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33932126
12.
Biaryl piperidines as potent and selective delta opioid receptor ligands.
Bioorg Med Chem Lett
; 20(2): 503-7, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20015649
13.
Prediction of Metabolite-to-Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model.
Clin Transl Sci
; 13(3): 520-528, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31880865
14.
Mini-Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME Study.
CPT Pharmacometrics Syst Pharmacol
; 9(8): 428-434, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32562380
15.
Recommendations for the Design of Clinical Drug-Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically-Based Pharmacokinetic Model.
CPT Pharmacometrics Syst Pharmacol
; 8(9): 685-695, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31215774
16.
Novel Application of the Two-Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin.
Clin Transl Sci
; 11(4): 405-411, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29575530
17.
Prediction of Losartan-Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically Based Pharmacokinetic Models.
J Pharm Sci
; 106(9): 2758-2770, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28412400
18.
A comprehensive listing of bioactivation pathways of organic functional groups.
Curr Drug Metab
; 6(3): 161-225, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15975040
19.
Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.
Drug Metab Dispos
; 34(9): 1443-7, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16760229
20.
Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding.
J Pharmacol Exp Ther
; 313(3): 1254-62, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15743928