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1.
Potent and selective bivalent inhibitors of BET bromodomains.
Nat Chem Biol
; 12(12): 1097-1104, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27775716
2.
Implementation and Challenges of Direct Acoustic Dosing into Cell-Based Assays.
J Lab Autom
; 21(1): 76-89, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26169025
3.
Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
J Med Chem
; 59(17): 7801-17, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27528113
4.
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Cancer Res
; 76(11): 3307-18, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27020862
5.
A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERDs).
J Biomol Screen
; 20(6): 748-59, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25851036
6.
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
J Med Chem
; 58(8): 3522-33, 2015 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-25790336
7.
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J Med Chem
; 58(20): 8128-40, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26407012
8.
Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
J Med Chem
; 59(7): 3576, 2016 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27003331
9.
AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer.
Clin Cancer Res
; 16(4): 1159-69, 2010 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20145185
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