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1.
Rapid and Definitive Identification of Cyclic Peptide Soft Spots by Isotope-Labeled Reductive Dimethylation and Mass Spectrometry Fragmentation.
Anal Chem
; 96(19): 7756-7762, 2024 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38690743
2.
Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling.
Chem Res Toxicol
; 35(3): 459-474, 2022 03 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35156375
3.
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem
; 44: 116275, 2021 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34314938
4.
Metabolite Identification of Therapeutic Peptides and Proteins by Top-down Differential Mass Spectrometry and Metabolite Database Matching.
Anal Chem
; 92(12): 8298-8305, 2020 06 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32402188
5.
Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion-Molecule Reactions Followed by Collision-Activated Dissociation.
Anal Chem
; 91(17): 11388-11396, 2019 09 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31381321
6.
Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
Bioorg Med Chem
; 27(13): 2905-2913, 2019 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31138459
7.
From molecules to visuals: Empowering drug discovery and development with mass spectrometry imaging.
J Mass Spectrom
; 59(5): e5029, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38656528
8.
Top-down interrogation of chemically modified oligonucleotides by negative electron transfer and collision induced dissociation.
Anal Chem
; 85(9): 4713-20, 2013 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23534847
9.
Applying Automation and High-Throughput MALDI Mass Spectrometry for Peptide Metabolic Stability Screening.
J Am Soc Mass Spectrom
; 34(6): 1196-1200, 2023 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37195067
10.
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.
Nucleic Acids Res
; 38(2): 660-71, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19917641
11.
Development and Application of DropletProbe Mass Spectrometry for Examining Biodistribution of Therapeutics.
Methods Mol Biol
; 2437: 171-180, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-34902148
12.
Mass spectrometry imaging of diclofenac and its metabolites in tissues using nanospray desorption electrospray ionization.
Anal Chim Acta
; 1233: 340490, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36283780
13.
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Bioorg Med Chem Lett
; 21(10): 3078-83, 2011 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21459573
14.
Optimization of dropletProbe-Mass Spectrometry for Whole-Body Tissue Distribution Analysis of Drug-Like Molecules.
J Am Soc Mass Spectrom
; 31(12): 2558-2562, 2020 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32538626
15.
Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II.
Anal Chim Acta
; 1125: 279-287, 2020 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32674774
16.
Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.
Bioorg Med Chem Lett
; 18(14): 3978-81, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18579375
17.
Allosteric inhibition of PTP1B activity by selective modification of a non-active site cysteine residue.
Biochemistry
; 44(21): 7704-12, 2005 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-15909985
18.
Small-molecule inhibition of TNF-alpha.
Science
; 310(5750): 1022-5, 2005 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-16284179
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