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1.
Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats.
Eur J Neurosci
; 59(10): 2436-2449, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38444104
2.
3,4-Methylenedioxypyrovalerone High-Responder Phenotype as a Tool to Evaluate Candidate Medications for Stimulant Use Disorder.
J Pharmacol Exp Ther
; 384(3): 353-362, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36627204
3.
The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys.
J Pharmacol Exp Ther
; 384(3): 372-381, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36507847
4.
Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.
J Chem Inf Model
; 61(9): 4266-4279, 2021 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-34420294
5.
Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.
Mol Pharmacol
; 89(1): 165-75, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26519222
6.
Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.
J Biol Chem
; 289(43): 29712-27, 2014 Oct 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-25179220
7.
Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.
ACS Pharmacol Transl Sci
; 7(2): 515-532, 2024 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38357284
8.
Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors.
Neuropsychopharmacology
; 2024 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38429498
9.
Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.
J Med Chem
; 67(1): 709-727, 2024 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38117239
10.
Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release.
Transl Psychiatry
; 13(1): 202, 2023 06 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37311803
11.
Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
J Pharmacol Exp Ther
; 339(2): 662-77, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21859929
12.
N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects.
J Pharmacol Exp Ther
; 336(2): 575-85, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21088247
13.
Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5.
Bioorg Med Chem Lett
; 21(9): 2650-4, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21295978
14.
Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3 Receptor Bitopic Ligands.
J Med Chem
; 64(20): 15313-15333, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34636551
15.
Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters.
ACS Pharmacol Transl Sci
; 4(2): 503-516, 2021 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33860180
16.
Novel Dual-Target µ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.
J Med Chem
; 64(11): 7778-7808, 2021 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34011153
17.
Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys.
J Pharmacol Exp Ther
; 334(2): 556-65, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20494958
18.
Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse.
J Pharmacol Exp Ther
; 333(3): 854-64, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20228156
19.
(±)VK4-40, a novel dopamine D3 receptor partial agonist, attenuates cocaine reward and relapse in rodents.
Br J Pharmacol
; 177(20): 4796-4807, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32851643
20.
Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability.
Eur J Med Chem
; 208: 112674, 2020 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32947229