Detalles de la búsqueda
1.
Discovery of novel 2-(4-(benzyloxy)-5-(hydroxyl) phenyl) benzothiazole derivatives as multifunctional MAO-B inhibitors for the treatment of Parkinson's disease.
J Enzyme Inhib Med Chem
; 38(1): 2159957, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36728713
2.
Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease.
J Enzyme Inhib Med Chem
; 37(1): 69-85, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34894968
3.
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem
; 35: 116074, 2021 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33640707
4.
Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents.
Bioorg Chem
; 111: 104895, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33887586
5.
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.
Bioorg Med Chem
; 28(8): 115400, 2020 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32146060
6.
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.
Bioorg Med Chem
; 28(7): 115374, 2020 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32089390
7.
Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease.
Bioorg Chem
; 97: 103707, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32146176
8.
Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation.
Bioorg Chem
; 94: 103477, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31818478
9.
Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation.
Bioorg Chem
; 84: 137-149, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30500523
10.
Design, synthesis and evaluation of chalcone Mannich base derivatives as multifunctional agents for the potential treatment of Alzheimer's disease.
Bioorg Chem
; 87: 395-408, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30921741
11.
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem
; 26(23-24): 6115-6127, 2018 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30470598
12.
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Bioorg Med Chem
; 26(5): 1102-1115, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29409707
13.
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-ß aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Bioorg Med Chem Lett
; 27(4): 718-722, 2017 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28131710
14.
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and ß-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorg Med Chem
; 25(6): 1997-2009, 2017 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28237559
15.
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem
; 25(3): 1030-1041, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28011206
16.
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Bioorg Med Chem
; 25(2): 714-726, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27923535
17.
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.
Bioorg Chem
; 71: 305-314, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28267984
18.
Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-ß-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 26(8): 2035-9, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26947607
19.
2-Hydroxy-4-benzyloxylimine Resveratrol Derivatives as Potential Multifunctional Agents for the Treatment of Parkinson's Disease.
ChemMedChem
; 18(6): e202200629, 2023 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36622947
20.
Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease.
Eur J Med Chem
; 249: 115142, 2023 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36716641