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1.
Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria.
Malar J
; 18(1): 38, 2019 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30767768
2.
Use of Optical Imaging Technology in the Validation of a New, Rapid, Cost-Effective Drug Screen as Part of a Tiered In Vivo Screening Paradigm for Development of Drugs To Treat Cutaneous Leishmaniasis.
Antimicrob Agents Chemother
; 61(4)2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28137819
3.
Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei.
Malar J
; 15(1): 588, 2016 Dec 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27923405
4.
Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections.
Malar J
; 13: 141, 2014 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24731238
5.
Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.
Malar J
; 13: 2, 2014 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-24386891
6.
The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models.
Eur J Drug Metab Pharmacokinet
; 39(4): 231-6, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24705994
7.
Animal Models in Regulatory Breakpoint Determination: Review of New Drug Applications of Approved Antibiotics from 2014-2022.
J Pers Med
; 14(1)2024 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38276233
8.
Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents.
J Med Chem
; 67(10): 8323-8345, 2024 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38722757
9.
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.
Malar J
; 12: 212, 2013 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-23782898
10.
Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy.
Eur J Drug Metab Pharmacokinet
; 37(1): 17-22, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22314893
11.
An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections.
ACS Cent Sci
; 8(8): 1145-1158, 2022 Aug 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36032774
12.
Correction to "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections".
ACS Cent Sci
; 8(9): 1362, 2022 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36188352
13.
Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice.
Malar J
; 10: 150, 2011 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-21645370
14.
Combination of Subtherapeutic Doses of Tretazicar and Liposomal Amphotericin B Suppresses and Cures Leishmania major-Induced Cutaneous Lesions in Murine Models.
ACS Infect Dis
; 7(2): 506-517, 2021 02 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33529014
15.
Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols.
Malar J
; 9: 51, 2010 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20149249
16.
Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases.
Bioorg Med Chem Lett
; 20(13): 3863-7, 2010 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20627564
17.
Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum.
Bioorg Med Chem Lett
; 20(4): 1347-51, 2010 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20097070
18.
In Vivo Bioluminescent Monitoring of Parasites in BALB/c Mouse Models of Cutaneous Leishmaniasis Drug Discovery.
Methods Mol Biol
; 2081: 81-106, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-31721120
19.
Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4-Kinase (Pfâ¯PI4KIIIß).
ACS Pharmacol Transl Sci
; 3(5): 948-964, 2020 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33073193
20.
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
J Med Chem
; 63(19): 10773-10781, 2020 10 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32667203