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1.
Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.
Bioorg Med Chem
; 28(5): 115261, 2020 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31987694
2.
Development of the ß-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells.
J Enzyme Inhib Med Chem
; 31(sup3): 117-130, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27476825
3.
The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.
J Pharmacol Exp Ther
; 335(2): 302-13, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20699436
4.
Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.
J Enzyme Inhib Med Chem
; 25(2): 180-94, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20222762
5.
Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.
Bioorg Med Chem
; 16(21): 9554-73, 2008 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18835176
6.
Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells.
J Enzyme Inhib Med Chem
; 23(5): 668-85, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18821256
7.
Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERß Activity.
J Med Chem
; 61(2): 514-534, 2018 01 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28426931
8.
Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold.
Biomedicines
; 4(3)2016 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28536383
9.
Combretastatin (CA)-4 and its novel analogue CA-432 impair T-cell migration through the Rho/ROCK signalling pathway.
Biochem Pharmacol
; 92(4): 544-57, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25450669
10.
ß-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.
J Med Chem
; 57(22): 9370-82, 2014 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25369367
11.
Novel cis-restricted ß-lactam combretastatin A-4 analogues display anti-vascular and anti-metastatic properties in vitro.
Oncol Rep
; 29(2): 585-94, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23232969
12.
"True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer.
J Med Chem
; 55(4): 1635-44, 2012 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-22280402
13.
BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.
Int J Mol Med
; 27(5): 715-23, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21369694
14.
Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.
Eur J Med Chem
; 46(9): 4595-607, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21840628
15.
Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents.
Eur J Med Chem
; 45(9): 3762-9, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20605274
16.
The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells.
Eur J Med Chem
; 45(5): 1873-9, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20122765
17.
Lead identification of conformationally restricted ß-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.
Eur J Med Chem
; 45(12): 5752-66, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-20933304
18.
Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
J Med Chem
; 53(24): 8569-84, 2010 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21080725
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