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1.
RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta-site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain.
J Labelled Comp Radiopharm
; 66(9): 222-236, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37095603
2.
Ocular Pharmacokinetics of Intravitreally Injected Protein Therapeutics: Comparison among Standard-of-Care Formats.
Mol Pharm
; 18(6): 2208-2217, 2021 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34014104
3.
Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease.
PLoS Comput Biol
; 16(10): e1008139, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33006965
4.
Ocular Half-Life of Intravitreal Biologics in Humans and Other Species: Meta-Analysis and Model-Based Prediction.
Mol Pharm
; 17(2): 695-709, 2020 02 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31876425
5.
Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.
Mol Pharm
; 15(7): 2770-2784, 2018 07 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29734810
6.
Translational PK/PD modeling to increase probability of success in drug discovery and early development.
Drug Discov Today Technol
; 21-22: 27-34, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27978984
7.
Combined treatment with a BACE inhibitor and anti-Aß antibody gantenerumab enhances amyloid reduction in APPLondon mice.
J Neurosci
; 34(35): 11621-30, 2014 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25164658
9.
International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs.
Clin Transl Sci
; 16(5): 723-741, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36651217
10.
Intravitreal Injection Planning during COVID-19 Pandemic: A Retrospective Study of Two Tertiary University Centers in Italy.
Healthcare (Basel)
; 11(3)2023 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36766862
11.
The dynamics of Aß distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat.
J Pharmacokinet Pharmacodyn
; 39(3): 227-37, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22481485
12.
Translating pharmacology models effectively to predict therapeutic benefit.
Drug Discov Today
; 27(6): 1604-1621, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35304340
13.
Understanding the Half-Life Extension of Intravitreally Administered Antibodies Binding to Ocular Albumin.
Pharmaceutics
; 12(9)2020 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32858986
14.
Are Ocular and Serum Half-Lives After Ranibizumab Intravitreal Injection Dependent on Dose?
Transl Vis Sci Technol
; 12(4): 9, 2023 04 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37040126
15.
Recent developments in using mechanistic cardiac modelling for drug safety evaluation.
Drug Discov Today
; 21(6): 924-38, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26891981
16.
Does the Fc Region Have a Role in the Ocular Half-life After Intravitreal Injection?
Invest Ophthalmol Vis Sci
; 61(5): 20, 2020 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32407522
17.
Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.
J Pharmacol Toxicol Methods
; 70(1): 73-85, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24879942
18.
PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation.
Biochem Pharmacol
; 85(11): 1684-99, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23454189
19.
Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus.
Eur J Pharm Sci
; 47(2): 375-86, 2012 Sep 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-22759901
20.
On the modeling of drug induced respiratory depression in the non-steady-state.
Annu Int Conf IEEE Eng Med Biol Soc
; 2008: 5564-8, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-19163978