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1.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25459880
2.
Catalytic in vivo protein knockdown by small-molecule PROTACs.
Nat Chem Biol
; 11(8): 611-7, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26075522
3.
Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics.
J Pharm Sci
; 109(10): 3160-3171, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32565354
4.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551024
5.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31265286
6.
N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I.
J Pharmacol Exp Ther
; 326(2): 432-42, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18499743
7.
Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2.
J Pharmacol Exp Ther
; 326(2): 443-52, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18499744
8.
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 9(10): 1039-1044, 2018 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30344914
9.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27109867
10.
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.
Cell Host Microbe
; 15(5): 623-35, 2014 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24746552
11.
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.
Sci Transl Med
; 4(159): 159ra148, 2012 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23136043
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