Detalles de la búsqueda
1.
Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches.
Mol Psychiatry
; 28(1): 202-216, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35665766
2.
The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aß production.
Cell Mol Life Sci
; 80(4): 97, 2023 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36930302
3.
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
J Biol Chem
; 296: 100489, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33662398
4.
Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains.
J Biol Chem
; 297(2): 100963, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34265307
5.
MT5-MMP controls APP and ß-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer's disease.
FASEB J
; 35(7): e21727, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34117802
6.
Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
Mol Psychiatry
; 26(10): 5592-5607, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33144711
7.
Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.
Acta Neuropathol
; 141(6): 823-839, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33881611
8.
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains.
Acta Neuropathol
; 141(1): 39-65, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33079262
9.
Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.
FASEB J
; 33(2): 2910-2927, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30332299
10.
Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease.
Int J Mol Sci
; 21(24)2020 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33327665
11.
Are N- and C-terminally truncated Aß species key pathological triggers in Alzheimer's disease?
J Biol Chem
; 293(40): 15419-15428, 2018 10 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30143530
12.
Amyloid ß production is regulated by ß2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.
J Biol Chem
; 292(24): 10153-10168, 2017 06 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-28476886
13.
Correction to: Intraneuronal aggregation of the ßCTF fragment of APP (C99) induces Aßindependent lysosomal-autophagic pathology.
Acta Neuropathol
; 146(4): 659-660, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37540291
14.
Neurolysin: From Initial Detection to Latest Advances.
Neurochem Res
; 43(11): 2017-2024, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30159819
15.
Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.
J Biol Chem
; 291(24): 12821-12837, 2016 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27059953
16.
The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease.
Mol Med
; 22: 905-917, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28079229
17.
Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.
Acta Neuropathol
; 134(5): 749-767, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28631094
18.
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
Acta Neuropathol
; 133(6): 955-966, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27933404
19.
Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
Mol Psychiatry
; 26(10): 5608, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-33398090
20.
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Cell Mol Life Sci
; 73(1): 217-36, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26202697