Detalles de la búsqueda
1.
mGlu2/3 receptor antagonists for depression: overview of underlying mechanisms and clinical development.
Eur Arch Psychiatry Clin Neurosci
; 273(7): 1451-1462, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-36715750
2.
Evaluation of the Safety, Tolerability, and Pharmacokinetic Profiles of TP0473292 (TS-161), A Prodrug of a Novel Orthosteric mGlu2/3 Receptor Antagonist TP0178894, in Healthy Subjects and Its Antidepressant-Like Effects in Rodents.
Int J Neuropsychopharmacol
; 25(2): 106-117, 2022 02 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34534292
3.
Vasopressin V1B Receptor Antagonists as Potential Antidepressants.
Int J Neuropsychopharmacol
; 24(6): 450-463, 2021 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33733667
4.
A Novel Potent and Selective Histamine H3 Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, and Wake-Promoting and Procognitive Effects in Rodents.
J Pharmacol Exp Ther
; 375(2): 276-285, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32862143
5.
Safety and pharmacokinetic profiles of MGS0274 besylate (TS-134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects.
Br J Clin Pharmacol
; 86(11): 2286-2301, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32353162
6.
Role of Serotonergic System in the Antidepressant Actions of mGlu2/3 Receptor Antagonists: Similarity to Ketamine.
Int J Mol Sci
; 20(6)2019 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30871246
7.
Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine.
Int J Neuropsychopharmacol
; 21(4): 371-381, 2018 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29309585
8.
No Sex-Specific Differences in the Acute Antidepressant Actions of (R)-Ketamine in an Inflammation Model.
Int J Neuropsychopharmacol
; 21(10): 932-937, 2018 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29893929
9.
Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine.
J Pharmacol Exp Ther
; 361(1): 9-16, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28115553
10.
Rapid and Sustained Antidepressant Action of the mGlu2/3 Receptor Antagonist MGS0039 in the Social Defeat Stress Model: Comparison with Ketamine.
Int J Neuropsychopharmacol
; 20(3): 228-236, 2017 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27765808
11.
Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report.
Int J Neuropsychopharmacol
; 20(4): 285-294, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28031269
12.
TASP0434299: A Novel Pyridopyrimidin-4-One Derivative as a Radioligand for Vasopressin V1B Receptor.
J Pharmacol Exp Ther
; 357(3): 495-508, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27029585
13.
Involvement of serotonergic system in the effect of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test.
J Pharmacol Sci
; 127(1): 57-61, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25704019
14.
Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor.
J Pharmacol Sci
; 127(3): 352-61, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25837934
15.
Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor.
J Pharmacol Exp Ther
; 351(3): 642-53, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25277141
16.
Is Metabolism of (R)-Ketamine Essential for the Antidepressant Effects?
Int J Neuropsychopharmacol
; 21(2): 154-156, 2018 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29294032
17.
The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide.
Behav Pharmacol
; 24(1): 74-7, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23268987
18.
Stimulation of metabotropic glutamate (mGlu) 2 receptor and blockade of mGlu1 receptor improve social memory impairment elicited by MK-801 in rats.
J Pharmacol Sci
; 122(1): 10-6, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23603933
19.
Antidepressants in the post-ketamine Era: Pharmacological approaches targeting the glutamatergic system.
Neuropharmacology
; 223: 109348, 2023 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36423706
20.
The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice.
J Pharmacol Sci
; 118(2): 295-8, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22293290