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1.
Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.
J Med Chem
; 50(10): 2301-9, 2007 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-17441703
2.
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
J Med Chem
; 49(2): 727-39, 2006 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-16420058
3.
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J Med Chem
; 47(24): 5912-22, 2004 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15537346
4.
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
J Med Chem
; 47(24): 5923-36, 2004 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15537347
5.
Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.
J Med Chem
; 47(5): 1175-82, 2004 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-14971897
6.
1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor.
Chem Biol Interact
; 213: 21-7, 2014 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24480521
7.
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J Med Chem
; 51(16): 5000-8, 2008 Aug 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18665583
8.
Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance.
Antimicrob Agents Chemother
; 49(11): 4465-73, 2005 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-16251284
9.
Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 49(10): 4046-51, 2005 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16189079
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